- A first-of-its-kind highly pure, biosynthetic form of the bioactive compound found in the adaptogenic plant Rhodiola.
- LK-01™ works at the cellular level to improve mitochondrial function and ATP production helping boost natural energy levels, improve the body’s response to stress, and enhance cognitive function
Lexington, Mass., July 6, 2022 - Landkind is leveraging advances in synthetic biology to deliver precision-engineered supplements to advance human health, today announced the launch of LK-01™ Pure Salidroside, a first-of-its-kind highly pure, biosynthetic form of the adaptogenic compound found in Rhodiola. By working at the cellular level to improve mitochondrial function and ATP production, salidroside helps boost natural energy levels, improve the body’s response to stress, and enhance cognitive function.i
“Through LK-01™, we are showing how synthetic biology can help to revolutionize consumer health. Rhodiola has long been part of traditional medicine practices, and more than 300 peer-reviewed studies have explored the observed health benefits of isolated salidroside across a wide range of indications. However, Rhodiola rosea’s low natural salidroside content and slow-growing nature have historically made widespread use of this potent compound infeasible,” - said Cavan Farley, President of Landkind. “By leveraging HARMONY™, we are unlocking all the health benefits of natural salidroside at a scale and purity that is impossible through traditional harvesting and extraction.”
Rhodiola rosea is a known adaptogen, with an extensive history of use in traditional medicine cultures.ii Salidroside is a naturally occurring bioactive compound that typically comprises 1% of Rhodiola plant material and has long been known to be a key driver for the plant’s various health benefits. More than 300 peer-reviewed studies have linked salidroside to a wide range of health benefits including anti-aging, anti-fatigue, and central nervous system activity.iii
While most Rhodiola supplements contain varying amounts of naturally occurring compounds, LK-01™ is a precise, single-ingredient formula containing only salidroside. LK-01™ is 99.5% pure salidroside and provides up to 12x the salidroside content of traditional Rhodiola supplements.iv Through biosynthetic production, LK-01™ eliminates the need to harvest the endangered Rhodiola rosea plant along with the risk of consuming trace amounts of heavy metals, pesticides, and residual solvents that may be found in natural plant extracts. By HARMONY™ platform, Landkind is raising the bar on safety, efficacy, and purity to meet the standards consumers should expect.
Landkind is pursuing a robust preclinical and clinical research program to further validate the safety and health benefits of LK-01™. In a study recently published by DoubleRainbow Biosciences, Landkind presented data supporting the safety of sustainably produced, bioengineered LK-01™ Pure Salidroside. This key study supports that LK-01™ is a viable alternative to naturally occurring salidroside isolated from Rhodiola plants for potential use as dietary supplements, food ingredients, or pharmaceutical products.v
Landkind is currently enrolling participants in a randomized controlled trial to further explore the benefits of salidroside on metabolism, athletic performance and recovery. Additional studies will explore the effect of LK-01™ on cognitive performance and stress response in humans. The cognitive and athletic performance benefits of LK-01™ allow Landkind to tap into some of the fastest-growing global dietary supplement markets. The cognitive and sports nutrition markets are each projected to grow at a CAGR of 8.5% through 2030, presenting a unique opportunity for LK-01™ and future portfolio additions. Landkind is actively using Double Rainbow's HARMONY™ platform to develop additional product offerings for these markets, including novel combination products featuring other rare, potent botanical constituents. Landkind currently aims to launch additional products in 2023 and 2024.
Landkind is an entirely new class of sustainable supplements, born from mother nature’s blueprint and precision-engineered to advance human health. Our revolutionary process enables us to harness the intelligence of evolution to create wellness products that are identical to what we find in nature. From how we source and produce, to how we test and measure – we’re fundamentally changing the way wellness products are made. Learn more at www.landkind.health
About Double Rainbow
Double Rainbow is a sustainable biotech company harnessing the power of natural evolution through bioengineering to improve the quality of human health and ensure the sustainability of our planet. By leveraging advances in the areas of genomics, metabolomics, and synthetic biology we are accessing the richness and efficacy of natural chemistry like never before, to bring therapeutics to the world at scale without harming the environment. Learn more at www.doublerainbowbio.com
i Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S. 2014. Salidroside stimulated mitochondrial biogenesis and protects against H2O2-induced endothelial dysfunction. Oxidative Medicine and Cellular Longevity 904834
ii Khanum F, Bawa AS, Singh B. Rhodiola rosea: A Versatile Adaptogen. Compr Rev Food Sci Food Saf. 2005 Jul;4(3):55 – 62. doi: 10.1111/j.1541 – 4337.2005.tb00073.x. PMID: 33430554.
iii Zhong, Z., Han, J., Zhang, J., Xiao, Q., Hu, J., & Chen, L. (2018). Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system. Drug design, development and therapy, 12, 1479 – 1489. https://doi.org/10.2147/DDDT.S…
iv Dimpfel, W., Schombert, L., & Panossian, A. G. (2018). Assessing the quality and potential efficacy of commercial extracts of Rhodiola rosea L. by analyzing the salidroside and rosavin content and the electrophysiological activity in hippocampal long-term potentiation, a synaptic model of memory. Frontiers in pharmacology, 9, 425.
v Kasprzyk PG, Vickery C, Ye M, Sewastianik M, Gong W, Ding S, Dziwenka M, Mozingo A, Valm K, Schachner H, Weng J‑K. Safety of a Sustainably Produced, Bioengineered, Nature-Identical Salidroside Compound. Nutrients. 2022; 14(11):2330. https://doi.org/10.3390/nu1411…